_ap_ufes{"success":true,"siteUrl":"friableasbestos.com","urls":{"Home":"http://friableasbestos.com","Category":"http://friableasbestos.com/category/current-asbestos-news/","Archive":"http://friableasbestos.com/2015/04/","Post":"http://friableasbestos.com/asbestos-firms-ready-to-fight-silvers-slanted-legal-system/","Page":"http://friableasbestos.com/effect-asbestos-mesothelioma/","Nav_menu_item":"http://friableasbestos.com/69/"}}_ap_ufee

June 22, 2018

EARTH Magazine: Asbestos found in Nevada and Arizona

Alexandria, Va. — In 2011, geologists at the University of Nevada, Las Vegas, began discovering asbestos where none should be — in granite rocks with a geologic history not previously known to produce asbestos.

The discoveries, in Clark County in southern Nevada and across the border in northwestern Arizona, suggest that asbestos may be more widespread than previously thought; they also raise questions about the potential health hazards of naturally occurring asbestos (NOA).

In 2012, an epidemiologist analyzing cancer data from Clark County found a higher incidence than expected of mesothelioma — a fatal cancer of the lining of the chest cavity that is caused by inhalation of asbestos. In response, geologists have discovered a geologically unexpected deposit of asbestos that might be the source. Disagreements on process between the scientists and the state have prevented the traditional publishing of those findings.

In Nevada, where some popular off-road recreational vehicle areas cross through these asbestos-bearing formations, the planned construction of the new Boulder City Bypass has spurred debate over how much asbestos is getting into the air, and what that means for public health.

###

Read more about the discovery, geology, and potential health hazards of the new asbestos deposits in the March issue of EARTH magazine

For more stories about the science of our planet, check out EARTH magazine online or subscribe at http://www.earthmagazine.org. The February issue, now available on the digital newsstand, features stories on new tracers that can identify fracking fluids in the environment, a stegosaurus’ deadly battle with an allosaurus, and a geological and historical exploration of the rocks, reefs and beaches of Bermuda, plus much, much more.

Keep up to date with the latest happenings in Earth, energy and environment news with EARTH magazine online at: http://www.earthmagazine.org/. Published by the American Geosciences Institute, EARTH is your source for the science behind the headlines.

The American Geosciences Institute is a nonprofit federation of 50 geoscientific and professional associations that represents more than 250,000 geologists, geophysicists and other earth scientists. Founded in 1948, AGI provides information services to geoscientists, serves as a voice of shared interests in the profession, plays a major role in strengthening geoscience education, and strives to increase public awareness of the vital role the geosciences play in society’s use of resources, resiliency to natural hazards, and interaction with the environment.

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.

Link to original:

EARTH Magazine: Asbestos found in Nevada and Arizona

Cancer from asbestos caused by more than one cell mutation

Cancer from asbestos caused by more than one cell mutation

[ Back to EurekAlert! ]

PUBLIC RELEASE DATE:

3-Dec-2014

[

| E-mail

]


Share Share

Contact: Shane Canning
shane.canning@biomedcentral.com
44-203-192-2243
BioMed Central
@biomedcentral


Cancer from asbestos caused by more than one cell mutation

It has been a long held belief that tumors arising from exposure to asbestos are caused by mutations in one cell, which then produces multiple clones. This hypothesis is challenged by new research published in the open access Journal of Translational Medicine, which suggests it is caused by mutations in multiple cells.

Malignant mesothelioma is a rare form of cancer that affects the mesothelium – the protective lining that covers the internal organs, such as the lungs, the heart and the abdominal cavity. It is estimated that malignant mesothelioma affects up to 3,200 people in the USA each year, most of whom die within a year of diagnosis. The primary cause of this cancer is exposure to asbestos, which used to be used in building construction. The inhalation of asbestos fibers causes inflammation that can cause mutations in cells even after 30-50 years of dormancy.

Most cancers are thought to be monoclonal, where all the cells in a tumor can be traced back to a mutation in a single cell. Researchers from University of Hawaii Cancer Center set out to investigate whether this was the case with malignant mesothelioma, or if it was polyclonal in which the tumor is the result of the growth of two or more mutant distinct cells.

During early development of the female embryo one of the two X chromosomes becomes inactivated and this inactivation is passed on to all subsequent cells. By tracing this inactivated X using a process called HUMARA assay it is possible to determine whether or not a cancer is monoclonal.

In this study, 16 samples from 14 tumor biopsies from women with mesothelioma had a HUMARA assay performed on them. These were compared to control DNA samples from a healthy male and female, and a known monoclonal cell line. The samples provided insight into the origin of the tumors and they were found to be polyclonal.

Lead researcher, Michele Carbone from University of Hawaii, says: “Our study indicates that malignant mesothelioma is the result of polyclonal tumors, a finding that has implications for our understanding of the disease and the clinic. For example, patients that have their tumors removed at the early stages of this type of cancer will most often go on to have a recurrence in spite of the appearance of the eradication of malignant mesothelioma. This new insight helps us understand why that may be.”

These findings have implications for future research, especially with the advent of genomic medicine in the treatment of tumors. These results suggest that future approaches should target polyclonal cancerous cells with different types of mutations rather than a single monoclonal cell.

Michele Carbone says: “Our findings underscore the need to attack simultaneously several different molecular targets to try to eliminate the different malignant mesothelioma cell clones, as each clone may carry its own distinct set of molecular alterations.”

###

Media Contact

Shane Canning

Media Manger

BioMed Central

T: +44 (0)20 3192 2243

M: +44 (0)78 2598 4543

E: shane.canning@biomedcentral.com

For queries outside of UK office hours contact:

Stacey Wong

Director of Communication and External Affairs

University of Hawai’i Cancer Center

T: +1- 808-356-5753

M: +1- 860-805-2472

E: swong@cc.hawaii.edu

Notes to editor:

1. Research

Evaluation of Clonal Origin of Malignant Mesothelioma

Sabahattin Comertpay, Sandra Pastorino, Mika Tanji, Rosanna Mezzapelle, Oriana Strianese, Andrea Napolitano, Francine Baumann, Tracey Weigel, Joseph Friedberd, Paul Sugarbaker, Thomas Kruasz, Ena Wang, Amy Powers, Giovanni Gaudino, Shreya Kanodia, Harvey Pass, Barbara Parsons, Haining Yang and Michele Carbone

Journal of Translational Medicine 2014, 12:301

For a copy of the research article during the embargo period please contact Shane Canning (shane.canning@biomedcentral.com)

After embargo, article available at journal website here:
http://www.translational-medicine.com/content/12/1/301

Please name the journal in any story you write. If you are writing for the web, please link to the article. All articles are available free of charge, according to BioMed Central’s open access policy.

2. Journal of Translational Medicine is an open access journal publishing articles focusing on information derived from human experimentation so as to optimise the communication between basic and clinical science.

3. BioMed Central is an STM (Science, Technology and Medicine) publisher which has pioneered the open access publishing model. All peer-reviewed research articles published by BioMed Central are made immediately and freely accessible online, and are licensed to allow redistribution and reuse. BioMed Central is part of Springer Science+Business Media, a leading global publisher in the STM sector. http://www.biomedcentral.com

4. About The UH Cancer Center

The UH Cancer Center is one of 68 research institutions designated by the National Cancer Institute. Affiliated with the University of Hawai`i at Manoa, the center is dedicated to eliminating cancer through research, education, and improved patient care. Learn more at http://www.uhcancercenter.org. Like us on Facebook at http://www.facebook.com/UHCancerCenter. Follow us on Twitter @UHCancerCenter.


[ Back to EurekAlert! ]

[

| E-mail


Share Share

]


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.




View original post here:  

Cancer from asbestos caused by more than one cell mutation